Brain imaging has revealed the neural power of enduring love. Bianca Acevedo (State University of New York) and colleagues found that the same brain regions associated with addictive reward were activated when either long term lovers (still in love after an average of 21 years' marriage) or short term lovers (together for an average of seven months) viewed images of their partners. "Those who experience long-term romantic love continue to crave union with their spouses and remain highly motivated to maintain, enhance and protect their relationships, just like those in early-stage intense romantic love," said co-author Helen Fisher (Rutgers University). There were some differences between the groups. For the long-term lovers only, regions associated with monogamous pair-bonds in animal studies were activated, as were regions associated with calmness and pain suppression. For the new lovers, regions associated with obsession were triggered.
A molecular mechanism has been identified which might explain the long lasting effects of childhood maltreatment into adulthood. Tania Roth and David Sweatt (University of Alabama at Birmingham) found that newborn rats raised by a stressed caregiver rat subsequently showed signs of what's called DNA methylation in their amygdala, right the way through into adulthood. Specifically, this 'epigenetic' chemical modification was found on the DNA associated with brain-derived neurotrophic factor – a protein which is important for the development of new brain cells and the support of existing ones. "This now opens the door for future studies to explore the significance of these epigenetic changes on [human] adolescent and adult emotional well-being," Roth said, "and importantly, to explore the efficacy of drugs aimed at reversing such epigenetic marks and addressing the behavioural deficits resulting from early mistreatment."
Researchers have discovered that there is more than one itch pathway to the brain – a finding that could open up new avenues for treatment. Frauke Kosteletzky (University of Erlangen-Nurnberg) and colleagues asked participants to report the sensations provoked by administration of either histamine or the tropical plant mucuna pruiens (cowhage). Cowhage was found to induce a sharper and more stinging sensation and also provoked stronger responses of the sympathetic nervous system. The two stimuli also responded differently to scratching which suggests they are processed differently in the brain. "Sticking cowhage spicules into healthy skin provokes a clear itch sensation, but not the 'flare reaction,' or reddening of the skin, characteristic of a histamine-mediated itch," said co-author Clemens Forster. "This suggests that other types of nerve fibres are causing the cowhage-induced itch."
The reward areas of cocaine addicts' brains are activated by 33 millisecond, subliminal presentation of drug-related paraphernalia, such as crack pipes and chunks of cocaine. Moreover, those addicts whose brains responded more to the subliminal presentation subsequently reported the strongest craving when shown visible cues. Anna Childress (University of Pennsylvania) and colleagues who made the new findings, said the areas activated by drug cues overlapped with brain areas normally activated by sexual images. "We have a brain hard-wired to appreciate rewards, and cocaine and other drugs of abuse latch onto this system," Childress said. "We are looking at the potential for new medications that reduce the brain’s sensitivity to these conditioned drug cues and would give patients a fighting chance to manage their urges."
Here's a tip if you don't want to gamble your money away: stay clear of on-line casinos and other betting opportunities when you haven't had a decent night's sleep. Vinod Venkatraman (Duke University) and colleagues found that after 24 hours without sleep, participants were drawn more to the possibility of large gains yet unfazed by the risk of heavy losses, compared with when they played the same gambling game after a good night's sleep. Moreover, these differences were supported by brain imaging data showing that sleep deprivation altered the participants' neural responses to losses and gains. "The advent of on-line gambling and 24-hour casinos have given us unprecedented opportunities for gambling into the night," said Venkatraman. "But it might be better for us to catch some sleep rather than staying up late gambling. We’re fighting more than just the unfavourable odds of the gambling machines."
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